Tadapox (Tadalafil, Dapoxetine)

Tadapox (Tadalafil 20mg, Dapoxetine 60mg) is a new hybrid combination treatment for erectile dysfunction (impotence) and premature ejaculation in one pill. Containing the active ingredients Tadalafil (20mg) and Dapoxetine (60mg), patients can experience a healthy erection and more control over the length of intercourse, so they can resume a normal sexual performance and enjoy an increase in the duration of sexual activity.

Tadalafil belongs to a group of medicines known as phosphodiesterase type 5 (PDE-5) inhibitors. It works by relaxing the blood vessels in your penis. This allows blood to flow into the penis and produce an erection when sexually aroused. This medicine will only help get an erection if you are sexually stimulated. It is very effective but needs to be taken at least 30 minutes before sexual activity. Dapoxetine belongs to the family of (SSRI) serotonin reuptake inhibitors. It is the only drug with regulatory approval in many countries for the treatment of premature ejaculation.

Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) enhances erectile function by increasing the amount of cGMP. Tadalafil inhibits PDE5. Because sexual stimulation is required to initiate the local release of nitric oxide, the inhibition of PDE5 by tadalafil has no effect in the absence of sexual stimulation.

Tadapox administered to healthy men produced no significant difference compared to placebo in supine systolic and diastolic blood pressure and in standing systolic and diastolic blood pressure. In addition, there was no significant effect on heart rate.

Dapoxetine is a short-acting selective serotonin reuptake inhibitor (SSRI) marketed for the treatment of premature ejaculation in men. Human ejaculation is primarily mediated by the sympathetic nervous system. The ejaculatory pathway originates from a spinal reflex center, mediated by the brain stem, which is influenced initially by a number of nuclei in the brain (medial preoptic and paraventricular nuclei).

The mechanism of action of Dapoxetine in premature ejaculation is presumed to be linked to the inhibition of neuronal reuptake of serotonin and the subsequent potentiation of the neurotransmitter’s action at pre– and postsynaptic receptors.

Dapoxetine inhibits the ejaculatory expulsion reflex by acting at a supraspinal level within the lateral paragigantocellular nucleus (LPGi). Postganglionic sympathetic fibers that innervate the seminal vesicles, vas deferens, prostate, bulbourethral muscles, and bladder neck cause them to contract in a coordinated fashion to achieve ejaculation. Dapoxetine has the ability to lengthen the time between sexual arousal and climax.

Tadapox quick tips:

• Long effective treatment time (up to 36 hours).
• Rapid onset of action (within 30 minutes).
• Increased stamina and performance.
• Prolonged duration of sexual intercourse.
• Can be purchased online with no prescription needed.